All times Central. Home games in CAPS.
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| REGULAR SEASON | | DATE | OPPONENT | RESULT | TV/RECORD |
| 3/31 | at Cleveland | L, 10-8 | 0-1 |
| 4/2 | at Cleveland | L, 7-2 | 0-2 |
| 4/3 | at Cleveland | W, 2-1 | 1-2 |
| 4/4 | at Detroit | W, 8-5 | 2-2 |
| 4/5 | at Detroit | W, 5-3 | 3-2 |
| 4/6 | at Detroit | W, 13-2 | 4-2 |
| 4/7 | MINNESOTA | W, 7-4 | 5-2 |
| 4/9 | MINNESOTA | L, 12-5 | 5-3 |
| 4/10 | MINNESOTA | Ppd. (rain) | 5-3 |
| 4/11 | DETROIT | L, 5-2 | 5-4 |
| 4/12 | DETROIT | W, 7-0 | 6-4 |
| 4/13 | DETROIT | W, 11-0 | 7-4 |
| 4/14 | OAKLAND | L, 2-1 | 7-5 |
| 4/15 | OAKLAND | W, 4-1 | 8-5 |
| 4/16 | at Baltimore | W, 3-1 | 9-5 |
| 4/17 | at Baltimore | L, 6-5 (10 inn.) | 9-6 |
| 4/18 | at Tampa Bay | W, 9-2 | 10-6 |
| 4/19 | at Tampa Bay | L, 5-0 | 10-7 |
| 4/20 | at Tampa Bay | W, 6-0 | 11-7 |
| 4/22 | N.Y. YANKEES | L, 9-5 | 11-8 |
| 4/23 | N.Y. YANKEES | L, 6-4 | 11-9 |
| 4/24 | N.Y. YANKEES | W, 7-6 | 12-9 |
| 4/25 | BALTIMORE | Ppd. | 12-9 |
| 4/26 | BALTIMORE | L, 5-1; W, 6-5 | 13-10 |
| 4/27 | BALTIMORE | W, 6-1 | 14-10 |
| 4/28 | BALTIMORE | 3-3 (susp.) • L, 4-3 (14 inn. on 8/25) | 14-10 |
| 4/29 | at Minnesota | L, 3-1 | 14-11 |
| 4/30 | at Minnesota | L, 4-3 | 14-12 |
| 5/2 | at Toronto | L, 2-0 | 14-13 |
| 5/3 | at Toronto | L, 5-3 | 14-14 |
| 5/4 | at Toronto | L, 4-3 | 14-15 |
| 5/5 | at Toronto | L, 1-0 | 14-16 |
| 5/6 | MINNESOTA | W, 7-1 | 15-16 |
| 5/7 | MINNESOTA | L, 13-1 | 15-17 |
| 5/8 | MINNESOTA | W, 6-2 | 16-17 |
| 5/9 | at Seattle | W, 4-2 | 17-17 |
| 5/10 | at Seattle | W, 8-4 | 18-17 |
| 5/11 | at Seattle | L, 6-3 | 18-18 |
| 5/12 | at L.A. Angels | L, 10-7 | 18-19 |
| 5/13 | at L.A. Angels | L, 2-0 | 18-20 |
| 5/14 | at L.A. Angels | W, 6-1 | 19-20 |
| 5/15 | at L.A. Angels | W, 4-3 | 20-20 |
| 5/16 | at San Francisco | W, 2-0 | 21-20 |
| 5/17 | at San Francisco | W, 3-1 | 22-20 |
| 5/18 | at San Francisco | W, 13-8 | 23-20 |
| 5/20 | CLEVELAND | W, 4-1 | 24-20 |
| 5/21 | CLEVELAND | W, 7-2 | 25-20 |
| 5/22 | CLEVELAND | W, 3-1 | 26-20 |
| 5/23 | L.A. ANGELS | L, 3-1 | 26-21 |
| 5/24 | L.A. ANGELS | L, 2-0 | 26-22 |
| 5/25 | L.A. ANGELS | W, 3-2 | 27-22 |
| 5/26 | at Cleveland | W, 6-3 (12 inn.) | 28-22 |
| 5/27 | at Cleveland | L, 8-2 | 28-23 |
| 5/28 | at Cleveland | W, 6-5 | 29-23 |
| 5/29 | at Tampa Bay | W, 5-1 | 30-23 |
| 5/30 | at Tampa Bay | L, 2-1 | 30-24 |
| 5/31 | at Tampa Bay | L, 2-0 | 30-25 |
| 6/1 | at Tampa Bay | L, 4-3 (10 inn.) | 30-26 |
| 6/3 | KANSAS CITY | W, 9-5 | 31-26 |
| 6/4 | KANSAS CITY | W, 6-4 (15 inn.) | 32-26 |
| 6/5 | KANSAS CITY | W, 6-2 | 33-26 |
| 6/6 | MINNESOTA | W, 10-6 | 34-26 |
| 6/7 | MINNESOTA | W, 11-2 | 35-26 |
| 6/8 | MINNESOTA | W, 12-2 | 36-26 |
| 6/9 | MINNESOTA | W, 7-5 | 37-26 |
| 6/10 | at Detroit | L, 6-4 | 37-27 |
| 6/11 | at Detroit | L, 5-1 | 37-28 |
| 6/12 | at Detroit | L, 2-1 | 37-29 |
| 6/13 | COLORADO | W, 5-4 | 38-29 |
| 6/14 | COLORADO | L, 2-0 | 38-30 |
| 6/15 | COLORADO | L, 5-3 | 38-31 |
| 6/17 | PITTSBURGH | W, 16-5 | 39-31 |
| 6/18 | PITTSBURGH | W, 8-2 | 40-31 |
| 6/19 | PITTSBURGH | W, 13-8 | 41-31 |
| 6/20 | at Cubs | L, 4-3 | 41-32 |
| 6/21 | at Cubs | L, 11-7 | 41-33 |
| 6/22 | at Cubs | L, 7-1 | 41-34 |
| 6/24 | at L.A. Dodgers | W, 6-1 | 42-34 |
| 6/25 | at L.A. Dodgers | L, 5-0 | 42-35 |
| 6/26 | at L.A. Dodgers | W, 2-0 | 43-35 |
| 6/27 | CUBS | W, 10-3 | 44-35 |
| 6/28 | CUBS | W, 6-5 | 45-35 |
| 6/29 | CUBS | W, 5-1 | 46-35 |
| 6/30 | CLEVELAND | W, 9-7 | 47-35 |
| 7/1 | CLEVELAND | W, 3-2 (10 inn.) | 48-35 |
| 7/2 | CLEVELAND | W, 6-5 | 49-35 |
| 7/3 | OAKLAND | L, 3-2 | 49-36 |
| 7/4 | OAKLAND | L, 7-1 | 49-37 |
| 7/5 | OAKLAND | W, 6-1 | 50-37 |
| 7/6 | OAKLAND | W, 4-3 | 51-37 |
| 7/8 | at Kansas City | W, 8-7 (13 inn.) | 52-37 |
| 7/9 | at Kansas City | W, 7-6 | 53-37 |
| 7/10 | at Kansas City | L, 4-1 | 53-38 |
| 7/11 | at Texas | L, 7-2 | 53-39 |
| 7/12 | at Texas | W, 9-7 | 54-39 |
| 7/13 | at Texas | L, 12-11 | 54-40 |
| 7/15 | All-Star Game at Yankee Stadium | W, 4-3 (15 inn.) | |
| 7/18 | KANSAS CITY | W, 9-5 | 55-40 |
| 7/19 | KANSAS CITY | L, 9-1 | 55-41 |
| 7/20 | KANSAS CITY | L, 8-7 | 55-42 |
| 7/21 | TEXAS | L, 6-1 | 55-43 |
| 7/22 | TEXAS | W, 10-2 | 56-43 |
| 7/23 | TEXAS | W, 10-8 | 57-43 |
| 7/25 | at Detroit | W, 6-5 | 58-43 |
| 7/26 | at Detroit | W, 7-6 | 59-43 |
| 7/27 | at Detroit | L, 6-4 | 59-44 |
| 7/28 | at Minnesota | L, 7-0 | 59-45 |
| 7/29 | at Minnesota | L, 6-5 | 59-46 |
| 7/30 | at Minnesota | W, 8-3 | 60-46 |
| 7/31 | at Minnesota | L, 10-6 | 60-47 |
| 8/1 | at Kansas City | W, 4-2 | 61-47 |
| 8/2 | at Kansas City | L, 9-7 | 61-48 |
| 8/3 | at Kansas City | L, 14-3 | 61-49 |
| 8/5 | DETROIT | W, 10-8 (14 inn.) | 62-49 |
| 8/6 | DETROIT | W, 5-1 | 63-49 |
| 8/7 | DETROIT | L, 8-3 | 63-50 |
| 8/8 | BOSTON | W, 5-3 | 64-50 |
| 8/9 | BOSTON | L, 6-2 | 64-51 |
| 8/10 | BOSTON | W, 6-5 | 65-51 |
| 8/11 | BOSTON | L, 5-1 | 65-52 |
| 8/12 | KANSAS CITY | W, 9-0 | 66-52 |
| 8/13 | KANSAS CITY | W, 4-0 | 67-52 |
| 8/14 | KANSAS CITY | W, 9-2 | 68-52 |
| 8/15 | at Oakland | L, 6-4 | 68-53 |
| 8/16 | at Oakland | W, 2-1 | 69-53 |
| 8/17 | at Oakland | W, 13-1 | 70-53 |
| 8/18 | SEATTLE | W, 13-5 | 71-53 |
| 8/19 | SEATTLE | W, 5-0 | 72-53 |
| 8/20 | SEATTLE | W, 15-3 | 73-53 |
| 8/22 | TAMPA BAY | L, 9-4 | 73-54 |
| 8/23 | TAMPA BAY | L, 5-3 | 73-55 |
| 8/24 | TAMPA BAY | W, 6-5 (10 inn.) | 74-55 |
| 8/25 | at Baltimore | L, 4-3 (14 inn.); W, 4-3 | 75-56 |
| 8/26 | at Baltimore | W, 8-3 | 76-56 |
| 8/27 | at Baltimore | L, 11-3 | 76-57 |
| 8/29 | at Boston | 6:05 p.m. | CSN |
| 8/30 | at Boston | 6:05 p.m. | WGN |
| 8/31 | at Boston | 12:35 p.m. | CSN/TBS |
| 9/1 | at Cleveland | 6:05 p.m. | CSN |
| 9/2 | at Cleveland | 6:05 p.m. | CSN |
| 9/3 | at Cleveland | 11:05 a.m. | WGN |
| 9/5 | L.A. ANGELS | 7:11 p.m. | CSN |
| 9/6 | L.A. ANGELS | 6:05 p.m. | WGN |
| 9/7 | L.A. ANGELS | 1:05 p.m. | CSN/TBS |
| 9/9 | TORONTO | 7:11 p.m. | CSN |
| 9/10 | TORONTO | 7:11 p.m. | WCIU |
| 9/11 | TORONTO | 7:11 p.m. | CSN+ |
| 9/12 | DETROIT | 7:11 p.m. | CSN |
| 9/13 | DETROIT | 2:55 p.m. | FOX |
| 9/14 | DETROIT | TBD | TBD |
| 9/15 | at N.Y. Yankees | 6:05 p.m. | CSN |
| 9/16 | at N.Y. Yankees | 6:05 p.m. | WCIU |
| 9/17 | at N.Y. Yankees | 6:05 p.m. | CSN |
| 9/18 | at N.Y. Yankees | 6:05 p.m. | WGN |
| 9/19 | at Kansas City | 7:10 p.m. | CSN |
| 9/20 | at Kansas City | 6:10 p.m. | WGN |
| 9/21 | at Kansas City | 1:10 p.m. | CSN |
| 9/23 | at Minnesota | 7:10 p.m. | WCIU |
| 9/24 | at Minnesota | 7:10 p.m. | CSN |
| 9/25 | at Minnesota | 7:10 p.m. | CSN+ |
| 9/26 | CLEVELAND | 7:11 p.m. | CSN+ |
| 9/27 | CLEVELAND | TBD | TBD |
| 9/28 | CLEVELAND | TBD | TBD |
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